Physics NEET Full Syllabus Mock Test 180 Question New Syllabus Mock Test - 11 PCB MCQ (Single Correct)

C-peptide of human insulin is:

A
A part of mature insulin molecule
B
Responsible for the formation of disulphide bridges
C
Removed during the maturation of proinsulin to insulin
D
Responsible for its biological activity

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The correct answer is:
C

Human insulin is initially synthesized as proinsulin. Proinsulin consists of the A-chain, B-chain, and C-peptide. During the maturation process, the C-peptide is cleaved off, leaving the A and B chains linked by disulphide bridges to form the active insulin molecule. The C-peptide itself does not have biological activity in regulating blood glucose but is important as a marker of insulin secretion. Therefore, it is removed during the conversion of proinsulin to insulin.

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